Dr. Mansoor Saleh: First human trials of drug to prevent death due to severe blood loss

Principal investigator Dr. Mansoor Saleh, M.D., professor in the Division of Hematology/Oncology, Department of Medicine, and director of the UAB Phase 1 Clinical Trials Program. (Image via UAB)
Principal investigator Dr. Mansoor Saleh, M.D., professor in the Division of Hematology/Oncology, Department of Medicine, and director of the UAB Phase 1 Clinical Trials Program. (Image via UAB)

By Bob Shepard
October 21, 2015.

The University of Alabama at Birmingham (UAB) will launch the first Phase 1 human trials of a drug — derived from the female hormone estrogen — that may help patients with severe bleeding survive long enough to get to appropriate medical care. A three year, $10 million U.S. Department of Defense contract from the Combat Casualty Care Research Program, U.S. Army Medical Research and Materiel Command, Fort Detrick MD, will fund studies of a synthetic estrogen molecule that may have a profound effect on an individual’s ability to survive major blood loss.

[…] “The work of Dr. Chaudry and colleagues showed that EE-3-SO4 is extremely effective in improving cardiovascular functions and boosting survival rates following injuries with extreme hemorrhage,” said principal investigator Mansoor Saleh, M.D., professor in the Division of Hematology/Oncology, Department of Medicine, and director of the UAB Phase 1 Clinical Trials Program. “This drug could have major implications for treating trauma, from battlefield injuries to life threatening hemorrhage following any injury. We are excited to be launching the first-in-human studies of this drug that was developed by one of our own here at UAB. This is a classic example of bench-to-bedside translational research.”

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Discover, Explore and Learn more via UAB News | UAB to start first human trials of drug to prevent death due to severe blood loss

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